Mechanistically, STAT3 is the downstream target gene of the miR-296-5p, and overexpression of exogenous STAT3 counteracted miR-296-5p-mediated enhancement of DDP chemosensitivity, indicating miRNA-296-5p promotes DDP chemosensitivity by targeting STAT3/KLF4 in NPC cells. Here, KLF4 is linked to nasopharyngeal carcinoma.