Interestingly, our results of qPCR showed that miR-296-5p agomir significantly inhibited the mRNA levels and protein expression of STAT3 and KLF4 in xenografted tumor tissues (Fig. 6D,F,G), which is consistent with the results of in vitro cell experiments, suggesting that miR-296-5p could enhance the sensitivity of nasopharyngeal carcinoma to cisplatin by downregulating STAT3 and KLF4 expression, and further promote tumor cell death. This evidence concerns the gene KLF4 and neoplasm.