IDH2 and familial dilated cardiomyopathy: Moreover, IDH2 was also significantly downregulated in all other transcriptomic data sets from failing genetic DCM, idiopathic DCM and ICM hearts, as well as from hearts of rodent models of genetic DCM, e.g., Mlp−/− and mutated phospholamban32Pln-R14Δ/Δ; ischemic DCM, e.g., myocardial infarction32; diabetic DCM, e.g., rats treated with streptozotocin (STZ)33 (Fig. 1f, g and Supplementary Fig. 1j).