We recently found hRpn13 to interact with epigenetic factors histone deacetylase HDAC8 and arginine deiminase PADI4 in myeloma cells where it contributes to NF-κB processing and transcriptional regulation of cytoskeletal and other proteins17; hRpn13 interaction with HDAC8 was previously found in glioblastoma cells18. Here, HDAC8 is linked to glioblastoma.