Elevated infiltration of CD8+ T cell and enhanced tumor killing effect are observed in both SCC patients and syngeneic murine SCC tumors with low expression of TP63. Given the prominent and indispensable role of IFNγ signaling for anti-tumor immunity30,31, we hypothesize that over-expression of TP63 promotes resistance to ICB therapy. This evidence concerns the gene TP63 and neoplasm.