To explore biological processes associated with TP63 expression in SCC patient samples, we interrogated RNA-seq data of 1077 patients and 112 cell lines (data were from TCGA and The Cancer Cell Line Encyclopedia (CCLE), respectively) representing three common types of squamous cancers, including lung squamous cell carcinoma (LUSC), head and neck squamous cell carcinoma (HNSC) and esophageal squamous cell carcinoma (ESCC). This evidence concerns the gene TP63 and cancer.