To mimic IFN conditions in the tumor microenvironment (TME), we added IFNγ exogenously in SCC cells since (i) IFNγ pathway is the most significant pathway negatively regulated by TP63, (ii) IFNγ receptors (IFNGR1, IFNGR2) have higher expression than IFNα receptors (IFNAR1, IFNAR2) in SCC cells. The gene discussed is IFNAR2; the disease is neoplasm.