LGR5 and diabetes mellitus: In a consanguineous family with diabetes of unknown etiology, we identified an uncharacterized heterozygous GLI2 missense variant (hg38 chr2:120990575; NM_001371271.1:c.4661 C > T; p.P1554L; rs767802807) (Fig. 1a, b; Supplementary Table 1).