Using FACS assay, we found that AMG-510 upregulated surface HER2 expression in different KRASG12C-mutant cell lines, including lung adenocarcinoma NCI-H2122 and NCI-H2030 (Fig. 9a) and colon adenocarcinoma SW837 and SW1463 (Supplementary Fig. 8a). The gene discussed is ERBB2; the disease is lung adenocarcinoma.