CXCL16 and neoplasm: Histological analysis of Ccne1-SIIN tumors showed an increased accumulation of transferred CXCR6-deficient OT-1 T cells in the tumor parenchyma relative to wildtype T cells (Fig. 5p, q), suggesting that releasing CD8+ T cells from CXCL16-CXCR6 mediated retention at the tumor margin can reverse T-cell exclusion.