In addition to the tumor cells (dsRED+), we also found another cell cluster lacking the expression of dsRED that similarly express mesenchymal genes, but which was enriched for additional genes previously associated with CAFs, such as Rarres2, Pi16, Fap, Lum, Sfrp2, Dpt, and Col14a1 (Fig. 2a, b)5,35. Here, PI16 is linked to neoplasm.