When we compared the total number of CAFs we did not find a significant difference (p = 0.380) between the Ccne1+ (mean = 45,027; SD = 9725) and Vgll3+ (mean = 68,194 mean; SD = 48,912) models (Fig. 3a) and the thickness of the stromal barrier quantified by the average distance of the CD90+ fibrotic stroma from the tumor invasive margin (Fig. 3b) was similar across the two models, suggesting that the number of fibrotic cells or thickness of the stromal barrier does not explain the differential distribution of CD8+ T cells between the Ccne1+ and Vgll3+ models. This evidence concerns the gene THY1 and neoplasm.