ACTA2 and carcinoma: Interestingly, glyCAF express genes associated with the contractile phenotype of myofibroblastic CAF (myCAF) identified in carcinomas (Acta2, Tagln, Myl9, Tpm1, Tpm2) (Supplementary Fig. 3c), suggesting that glyCAF share myCAF features, but ultimately represent a specific metabolic cell state that is distinct from the myofibroblastic CAF previously described in carcinomas15,18.