Specifically, several obesity-related genes, such as fatty acid binding protein 2 (FABP2) and FABP5, exhibited a loss of m6Am in their mRNAs, leading to a significant downregulation of protein expression due to the overexpression of FTO under HFD conditions (Ben-Haim et al., 2021). The gene discussed is FABP2; the disease is obesity due to melanocortin 4 receptor deficiency.