HSPA9 and myelodysplastic syndrome: We inhibited the expression of HSPA9 in these cells using gene knockdown or an allosteric inhibitor and assessed erythroid maturation.25, 26 We have previously identified that HSPA9 knockdown induces apoptosis in human CD34+ cells, which is likely a TP53-dependent process, suggesting that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS.27