Despite lacking a statistically significant difference, tumor cells expressing CD47-IgV induced higher mortality and more rapid death than those expressing CD47-iso2 in immunocompetent BALB/c mice (mortality rates and median survival times for the CD47-IgV and CD47-iso2 groups were 90% vs. 70% and 59.5 days vs. 79 days, respectively; Figure 2D), likely due to the defect of CD47-IgV in transmitting death signals (Figure 1B). Here, CD47 is linked to neoplasm.