Another aspect to highlight is the correlation between polylactosaminelevels and enhanced invasion and metastasis, as seen in SW620, LS174T,and LoVo CRC cells.86 In a previous study,we reported increased proliferation, colony formation, and a moremesenchymal phenotype in FUT8-knockdown SW480 cells,28 which is consistent with the current findingsof highly branched/polylactosamine N-glycans in SW480cells defective in FUT8 expression. The gene discussed is FUT8; the disease is colorectal carcinoma.