Likewise, XRCC5 silencing led to an enhanced cisplatin radiosensitization in a cervicalcarcinoma cell line model,117 and XRCC6-knockdown enhanced radiosensitivity in mammal cells,118 and chemosensitivity to cisplatin in bladdercancer.119 These results indicate thatthe inhibition of XRCC5 or XRCC6 improves the effectiveness of chemotherapyused in CRC, such as platinum-based drugs and/or radiotherapy. Here, XRCC6 is linked to colorectal carcinoma.