This is the case of increasedlevels of calnexin (CANX), which has been described as a potentialbiomarker of poor prognosis in CRC patients and whose knockdown inHCT116 CRC cells led to increased chemosensitivity to 5-FU and reducedclonogenic survival.96 Likewise, heat shockproteins such as HSP90AA1, HSP90AB1, and HSPA8 were also altered inCRC. This evidence concerns the gene HSPA8 and colorectal carcinoma.