Disruption of the glycosylation machinery is a commonfeature inmany types of cancer, and colorectal cancer (CRC) is no exception.Core fucosylation is mediated by the enzyme fucosyltransferase 8 (FucT-8),which catalyzes the addition of α1,6-l-fucose to theinnermost GlcNAc residue of N-glycans. The gene discussed is FUT8; the disease is colorectal cancer.