FUT8 and colorectal carcinoma: Compared with normalepithelium, CRC cells have elevated levels of high-mannose N-glycans.62 Several N-glycome studies have demonstrated the differential distributionof glycan species depending on the stage of CRC.63,64 If we stick to the hypothesis of incomplete synthesis and/or neosynthesis,the silencing of FUT8 in the SW480 and SW620 lineswould favor neosynthesis, as suggested by the significant expressionof complex forms; consequently, their cellular malignancy would beenhanced.