We found that DR genes were mainly enriched in processes involving AMP-activated protein kinase (AMPK), NRF2-mediated oxidative stress response, mammalian target of rapamycin (mTOR), and NF−κβ signalling that have been reported to mediate the anti-cancer effects of DR58, 59, 60, 61 (Figure S1a). This evidence concerns the gene NFKB1 and cancer.