WDFY4 and autoimmune disease: Overall, although the allele frequency of multiple variants in the WDFY4 gene in different ancestry populations varies and shows different linkage disequilibrium patterns (Supplementary Fig. S2, available at Rheumatology online), 10 variants associated at genome-wide significance (p ≤ 5 × 10−8) have been reported consistently associated with autoimmune diseases according to the GWAS Catalog database [6] (Table 1; Fig. 1A).