Recently, WDFY4 variant rs7919656 was reported to be associated with rapidly progressive interstitial lung disease (RP-ILD) in anti-melanoma differentiation-associated gene 5 autoantibody-positive dermatomyositis (MDA5+DM) [2], could be a promising tool to predict poor prognosis in newly diagnosed MDA5+DM patients and thus influence management strategy. The gene discussed is WDFY4; the disease is interstitial lung disease.