MOG and glycogen storage disease VI: This variability can lead to different levels of activation of the innate immune system30 and disease manifestations, with high levels of MOG causing a chronic, non-remitting disease model and low levels of MOG inducing a relapsing-remitting disease course.31 Additionally, it is known that environmental factors can influence the development of EAE, indicating that the same dose of EAE induction reagents will not produce the same condition across all facilities.32