In human postmortem brains across different Braak stages of AD severity, HSPB1 is predominantly detected in astrocytes, as shown by its preferential location within cells positive for the general astrocyte marker aldehyde dehydrogenase 1 family member L1 (ALDH1L1) (Fig. 1A and fig. The gene discussed is HSPB1; the disease is Alzheimer disease.