Among NSCs harboring EGFR alterations, NPE-IE cells have been reported to generate brain tumors in immunocompetent mice.9 Therefore, we selected NPE-IE cells to test the effect of TAT-Cx43266–283 on the development of tumors derived from NSCs harboring EGFR alterations and other GBM driver mutations. This evidence concerns the gene EGFR and glioblastoma.