Thus, Src may phosphorylate EGFR and EGFRvIII triggering their downstream signaling5,24–27 associated with oncogenesis and tumor progression.28,29 Therefore, the interaction between Src and EGFR/EGFRvIII is involved in cell transformation, and it is considered an interesting target for cancer therapy.5,28,30,31. Here, EGFR is linked to neoplasm.