First, we analyzed TAT-Cx43266–283 effect on the cell viability of SVZ NSCs from p16/p19 KO mice (SVZ-NSCs) with overexpression of EGFRwt (SVZ-EGFRwt) or EGFRvIII (SVZ-EGFRvIII).15 While 100 μM TMZ did not affect cell viability in SVZ-NSCs with or without EGFR or EGFRvIII, TAT-Cx43266–283 only decreased cell viability in NSCs overexpressing EGFR or EGFRvIII, but not in SVZ-NSCs (Figure 3A and B), supporting the role of EGFR signaling in TAT-Cx43266–283 effect and confirming the selectivity of TAT-Cx43266–283 in tumor cells. This evidence concerns the gene EGFR and neoplasm.