The study results demonstrated that compared with the ALD and ML385 groups, PCP and Fer-1 enhanced the Nrf2 signal in BRL3A cells, increased Ho-1 levels, strengthened antioxidant ability, reduced lipid peroxidation product MDA, inhibited Keap-1 activity, decreased ROS generation, and consequently inhibited lipogenesis and accumulation, improving alcohol-induced hepatic steatosis. Here, NFE2L2 is linked to alcohol drinking.