Further individual examination of marker genes for MC3 (n = 55) and MC5 (n = 254) found that the enrichment of the lysosome/endolysosome components, while observed in both MCs, was particularly dominant in MC3 (S3C Fig), the cluster that was more strongly associated with poor survival in GBM patients [24]. The gene discussed is MC3R; the disease is glioblastoma.