First, we assessed the relationship between the 21 MC3 genes and a set of four genes representative of GBM’s immunosuppressive microenvironment: the immunosuppressive TAM markers MRC1 (CD206) and CD163 [21] and the immunosuppressive cytokines IL10 and TGFB1 [21, 23], and found overwhelmingly positive correlations between these two groups of genes (Fig 4A and 4B, S4 Fig, and S1 Table). This evidence concerns the gene MC3R and glioblastoma.