Non-SUMOylated HuR shows an enhanced interaction with RNAs related to cell-cycle control and DDR, mitochondrial and ER functionality, and Ubl-PTMs, which would explain the observed senescent phenotype and regulation of the SUMOylation process in the HuH-7 cell lines, as SUMOylated HuR would continue driving HCC progression. Here, ELAVL1 is linked to hepatocellular carcinoma.