Increased arthritis disease activity was associated with higher levels of inflammatory cytokines, including IL-6 (rs(156) = 0.24, p = 0.03) and TNF (rs(156) = 0.21, p = 0.009) and immunoregulatory cytokine IL-10 (rs(156) = 0.17, p = 0.03). The gene discussed is TNF; the disease is Arthritis.