Similarly, Chotipakornkul et al. have identified a higher cut-off value of basal LH of 0.2 mIU/L which combined with basal LH/FSH ratio (cutoff: 0.1) could easily and cost-effectively diagnose CPP in a girl in breast Tanner stage II, with 71.4% and 100% of sensitivity and specificity, respectively [46]. This evidence concerns the gene BRD2 and central precocious puberty.