A nested case–control study of 6 cohort studies with 1655 subjects, 565 SCD cases, and 1090 controls reported that several common biomarkers like total cholesterol to high-density lipoprotein cholesterol ratio, cardiac troponin I, NT-proBNP, and hs-CRP were independent and cumulative risk factors of SCD [75]. This evidence concerns the gene NPPB and Schnyder corneal dystrophy.