Based on GO and KEGG analyses, we observed that the functional network of CELSR3 in HNSCC was related to methyltransferase complex, ATPase complex, chromosomal region, integrator complex, where they were involved in microtubule organizing center organization, double-strand break repair, protein alkylation, chromatin assembly or disassembly. The gene discussed is CELSR3; the disease is head and neck squamous cell carcinoma.