Using the data from TCGA, we found that CELSR3 expression was significantly elevated in 21 of 33 cancer types, including bladder urothelial carcinoma (BLCA), bladder urothelial carcinoma (BRCA), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), kidney renal esophageal carcinoma (ESCA), kidney renal clear cell carcinoma (KIRC), among others (Fig. 1A). The gene discussed is CELSR3; the disease is cholangiocarcinoma.