NFE2L2 and ischemia: (Chen et al. 2015) revealed that in the endothelial cell, NRF2–KEAP1 signaling plays a significant role in modulating the redox homeostasis, thus preventing several cardio-metabolic diseases like atherosclerosis, hypertension, aging, and ischemia, through combination with antioxidant response elements (ARE) and subsequently promoting several antioxidant genes transcription.