Interestingly, the prognostic significance of the HSD3B1 adrenal-permissive genotype is relevant to other hormonally driven tumors, including estrogen receptor-positive breast cancer, human epidermal growth factor receptor–negative breast cancer, and endometrial cancer, which may potentially be associated with promoting androstenedione conversion to estrone by aromatase, thereby contributing to worse clinical outcomes.20 The gene discussed is ESR1; the disease is endometrial cancer.