GPX4 and metabolic dysfunction-associated steatohepatitis: For ferroptosis, researchers found that in methionine/choline-deficient diet (MCD) feeding mice, RSL-3 (ferroptosis inducer) can decrease the GPX4 expression and aggravate the disease severity, whereas GPX4 activator sodium selenite and ferroptosis inhibitor liproxstatin-1 (Lip-1) can alleviate the NASH in mice (64).