In prostate cancer cells with overexpressed PALI1, the G9A-PALI1-PRC2.1 supercomplex is formed, which mediates H3K9me2/H3K27me3 dual methylation at a set of promoters that are originally G9A targets, leading to gene repression that is more robust than could be caused by H3K9me2 alone (Fong et al., 2022). Here, EHMT2 is linked to prostate carcinoma.