EHMT2 and Familial prostate cancer: In prostate cancer cells with overexpressed PALI1, the G9A-PALI1-PRC2.1 supercomplex is formed, which mediates H3K9me2/H3K27me3 dual methylation at a set of promoters that are originally G9A targets, leading to gene repression that is more robust than could be caused by H3K9me2 alone (Fong et al., 2022).