To determine the specific genes that might be involved in the role of ICOS in CRC, 10 mRNAs (IKZF1, KLHL6, PLEK, SLAMF1, CYBB, IRF4, PIK3CG, P2RY13, PRKCB, and PTPRC) were considered as key genes as they ranked as top 10 in both the networks (Supplementary files 6 and 10). Here, KLHL6 is linked to colorectal carcinoma.