CD274 and cancer: In addition, in early clinical studies, it was found that blocking the CTLA‐4 pathway can prolong T‐cell response time, destroy cancer cells, and mediate T‐cell invasion of tumor tissue, thus leading to tumor regression and prolonged survival, while PDL1 was found to be highly expressed in a variety of tumor models, and blocking this pathway could also effectively enhance the killing effect of T cells and mediate tumor regression.7