CEACAM5 and neoplasm: Tiernan et al. (2015) were the first to show specific tumour fluorescence imaging using NIR669-doped silica nanoparticles (mean diameter of 65 nm) in the LS174T murine xenograft mouse model.26 They immobilised monoclonal anti-CEA antibody to the surface of the nanoparticle using the PAMAM dendrimer.