In breast cancers, homotypic CTC clusters demonstrate remarkable resilience against anoikis by preserving cell–cell contacts through a variety of complexes, including plakoglobin (JUP) (Aceto et al., 2014), homophilic CD44 interactions (Liu et al., 2019), E-cadherin (CDH1) (Padmanaban et al., 2019) and nectin-4 (Brown et al., 2018) (Fig. 2B). Here, NECTIN4 is linked to breast cancer.