Besides, studies have shown that remnant cholesterol may play a key role in the development of NAFLD/NASH,66, 67 while TM6SF2 may play an inhibitory role in this process, and TM6SF2 deficiency promoted the development of hepatic steatosis, hepatic fibrosis and liver cancer.68, 69. Here, TM6SF2 is linked to Hepatic fibrosis.