TM6SF2 and metabolic dysfunction-associated steatohepatitis: Besides, studies have shown that remnant cholesterol may play a key role in the development of NAFLD/NASH,66, 67 while TM6SF2 may play an inhibitory role in this process, and TM6SF2 deficiency promoted the development of hepatic steatosis, hepatic fibrosis and liver cancer.68, 69