Additionally, based on the CCK‐8, colony formation, Transwell migration/invasion and EdU assays, LY294002 led to a significant reverse of the MRPS16 effect on enhancing H23 and H2030 cell proliferation (Figure 5A–C and Figure S3C), which was parallel to the in vitro study which verified that LY294002 treatment significantly decreased tumour growth in mice with subcutaneous xenograft more than in the corresponding groups (Figure S4A). Here, MRPS16 is linked to neoplasm.