These results are somehow in contrast with the observation that high IS concentrations (250 μM), as found in patients with advanced CKD, elicited an oxidative stress‐based damage through NRF2 downregulation,35 but the discrepancy can be explained by the fact that the IS‐induced effects are non‐linearly dose‐dependent. The gene discussed is NFE2L2; the disease is chronic kidney disease.