The activation of the STING pathway by VPS34 inhibition was not limited to the RCC cells but similarly observed in the Me30966 melanoma cell line as evidenced by increased IRF3 and STAT1 phosphorylation (lanes 3 and 5) in a STING‐dependent manner (lanes 4 and 6) (Fig. S2B). Here, PIK3C3 is linked to renal cell carcinoma.