CNR1 and encephalitis: Alterations of the endocannabinoid system in postmortem tissue of PLWH has been demonstrated previously with reported changes in CB1R and CB2R expression in the frontal lobe (Cosenza-Nashat et al., 2011; Swinton et al., 2021), as well as increases in FAAH expression in cortical postmortem tissue samples from rhesus monkeys infected with simian immunodeficiency virus displaying encephalitis (Benito et al., 2005).