CD40LG and irritable bowel syndrome: Antibodies against gonadotropin-releasing hormone (GnRH) and a reduced number of GnRH-containing neurons in the ENS were sporadically found in patients with IBS (Ohlsson et al., 2010), and 11 out of 26 patients with IBS were found to be positive for IgM antibodies to GnRH (Ohlsson et al., 2011).