WAOs were co-cultured with mice macrophages in the alginate hydrogel mixture without impairing the adipogenic differentiation capacity to model insulin-resistance 83,84,112,122, characterized by lower p-AKT and GLUT4 expressions 83,84,122 and insulin-stimulated glucose uptake (ISGU) level94,95,12 than in the mono-culture system. Here, SLC2A4 is linked to Insulin resistance.