We further validated that the representative core genes in the IL-6/JAK/STAT3 pathway (Il6st (Gp130), Fas and Stat1) and the late response of estrogen (St6gal, Areg and Serpina3) were highly reduced in shMCT-1 tumor when compared to scramble tumor (Figure 2F). The gene discussed is STAT3; the disease is neoplasm.