After fed an HFD containing 20% fat, 0.5% cholesterol for 3 months, ApoA5-/- hamsters showed severe combined hyperlipidemia with triglyceride levels more than 25,000 mg/dL and total cholesterol levels higher than 4000 mg/dL, while HDL-C levels were still lower in ApoA5-/- hamsters than WT hamsters (Figure 4A-4C). Here, APOA5 is linked to hyperlipidemia.