Therefore, to exclude the interference of very large TG rich lipoproteins, it will be tempting for us to further validate whether ApoA5 deficiency can cause an increased incidence of ASCVD by crossing ApoA5-/- hamsters with LDLR-deficient background or by overexpressing PCSK9 in liver in the future study. This evidence concerns the gene APOA5 and atherosclerosis.