In ApoC2-/- hamsters under chow diet condition, plasma LPL activity was completely abolished in the absence of its obligatory cofactor ApoC2 and circulating TG concentration was incredibly increased to 8000-10000 mg/dL, accompanied by hypercholesterolemia with TC level near to 1000 mg/dL, whereas with the same nutrient treatment, ApoA5-/- hamsters showed a reduction in LPL activity by 50%, which was consistent with the observations in ApoA5-deficient patients37, leading to HTG with TG level at 2000-3000 mg/dL and a moderate increase in TC level to 200-300 mg/dL. The gene discussed is LPL; the disease is familial hypercholesterolemia.