APOA5 and metabolic dysfunction-associated steatotic liver disease: Furthermore, a study led by Sharma et al showed that AAV-mediated overexpression of human ApoA5 significantly reduce plasma TG levels, but the impact of ApoA5 overexpression on hepatic lipid contents in ApoA5-/- mice has not been extensively investigated yet 17, making the relationship between HTG and NAFLD elusive.