Here, immunofluorescence was performed to examine TREM2+ MФs alteration in human skin lesions of diffuse cutaneous SSc (dcSSC) and localized scleroderma (LS), and found that there was a dramatic upregulation of CD68+TREM2+ MФs during skin fibrosis progression (Figure 1A-B). This evidence concerns the gene TREM2 and localized scleroderma.