In addition, we found TREM2+ MФs in human SSc had similar features with that of mouse skin fibrosis after BLM-treatment (Figure 6), demonstrating TREM2+ MФ signatures appeared to be conserved between the two species, and the mouse model of skin fibrosis induced by BLM treatment might better reflect the pathogenesis of human dcSSc. Here, TREM2 is linked to systemic sclerosis.