Further analysis showed 24 genes (C1qb, Ly63, Lst1, Msr1, Runx1, Spi1 et al.)in TREM2+ MФ-conserved signature from BLM-treated skin were also expressed by the equivalent compartment from mouse fetal skin (Figure 6B, Supplementary Table S10), which was much more than TREM2- MФs (4 genes) (Supplementary Figure S5B, Supplementary Table S11). This evidence concerns the gene C1QB and Bloom syndrome.