ERBB2 and cancer: In one such example, mRNA-loaded EVs expressing anti-HER2+ antibodies were systemically administered to deliver functional HchrR6 mRNA with the prodrug C16H7CIN2O4 (CNOB) to HER2+ cancer cells in a HER2 overexpressing mouse model and achieved significant near-complete growth-arrest of tumors compared to controls treated with free prodrug or unloaded EVs 116.