In APAP-induced acute liver failure patients (GSE74000), IKBKG levels decreased, and Nrf2 target genes were also repressed (i.e., HMOX1, PRDX1, TXNRD1, GPX4, GPX1, GCLC, GCLM, and NQO1) (Figure 5C). Here, GPX4 is linked to acute liver failure.