ECM-myCAFs, wound-myCAFs and TGFβ-myCAFs are in regions with high TGF-β signaling. Recent single-cell studies 25 determined that in BC, there are several major CAF subpopulations: ECM-myCAFs, TGFβ-myCAFs, wound-myCAFs, IFNαβ-myCAFs, acto-myCAFs, IFNγ-iCAFs, detox-iCAFs, and IL-iCAFs. This evidence concerns the gene TGFB1 and breast cancer.