Moreover, the spleen can also function as an extra reservoir of monocytes that are readily released in inflammatory conditions 14, 52, and splenic monocytes are able to migrate into the liver through the modulation of CX3CL1-CX3CR1 and CCL2-CCR2 axis and participate in the progression of hepatic fibrosis 16, 20, 21, 53. This evidence concerns the gene CCL2 and Hepatic fibrosis.