CSF1R and Hepatic fibrosis: In this study, we reported that the splenic classical monocytes (CD11b+ CD115+ CX3CR1low Ly6Chigh), but not non-classical monocytes (CD11b+ CD115+ CX3CR1high Ly6Clow) aggravated the hepatic fibrosis with increased collagen deposition and up-regulation of hepatic stellate cells (HSCs) activation by secreting pro-inflammatory and profibrotic cytokines (Figure 4B-D).