CX3CR1 and Hepatic fibrosis: In this study, the number of CX3CR1+ cells markedly increased in the CCl4-induced fibrotic liver (Figure 1G) and spleen (Figure S1D), whereas splenectomy alleviated liver fibrosis (Figure 1 B-C) and reduced the number of CX3CR1+ cells (Figure 1G) and their subsets (CX3CR1+ non-classical and classical Mon/Mφs) (Figure 1I and 1K).