PIK3C2B and head and neck squamous cell carcinoma: Mutations in KMT2D and PIK3C2B were also associated with trends toward worse overall survival in TCGA HNSCC patients compared to WT (KMT2D, p = 0.10, PIK3C2B, p = 0.08), but mutations in the NF1 and TGFBR2 were not significantly associated with prognosis in TCGA (p = 0.8 for both, Supplementary Figure S3).