However, several persistent tumors were characterized by HPV-negative non-oropharyngeal states, including T0 and T3 states (predominantly the oral cavity, characterized by the upregulation of EGFR-p63 and NFkB-SRC-JUN pathways and the downregulation of DNA Repair-MYC-E2F) and T8 (predominantly larynx cancer and current/former smokers, characterized by the upregulation of NRF2-PPP and PI3K-EMT pathways). The gene discussed is EGFR; the disease is laryngeal neoplasm.