When sequenced FFPE tumors were projected onto tumor states and archetypes, tumors responsive to treatment (purple) clustered in state T2, characterized by EGFR-p63/WNT and downregulation of EMT-ZEB1 and DNA Repair-MYC-E2F, and associated with HPV-positive oropharyngeal tumors (Figure 4). Here, ZEB1 is linked to neoplasm.