Other genes harboring mutations among 40% (n = 2) of persistent HPV-positive OPSCC tumors were NF1, KMT2D, PIK3C2B, and TGFBR2. The mean tumor mutational burden was 12.96 Mut/Mb (range, 2–36.05). The gene discussed is PIK3C2B; the disease is neoplasm.