The tumors were defined by nine tumor states (Figure 3A), each characterized by the differential activity of nine key pathways: NRF2-PPP, NFkB-SRC-JUN, TCA Cycle, DNA Repair-MYC-E2F, PI3K-EMT-Stem, WNT-BCAT-AKT, NFkB-IRF-KLF5, EGFR-p63, and EMT-ZEB1. The gene discussed is ZEB1; the disease is neoplasm.