SPP1 and cancer: Areas of cancer tissue had significantly more highly expressed genes involved in matrix remodelling, including COL1A1, COL1A2, COL3A1, COL6A3, CEACAM6, FN1 and many genes previously reported to be over-expressed in cancer, including CCND1, SPP1, MYC, CTNNB1 and RHOB, when compared to histologically normal tissue and inflamed tissue (Figure 4A).