Research on Lachnoclostridium, which our study has identified as positively associated with PAD, has shown that supplementing with plant Lactobacillus FRT10 can significantly reduce the abundance of Lachnoclostridium, which in turn can considerably lower body weight gain and liver concentrations of triglycerides and alanine transaminase (Cai et al., 2020). This evidence concerns the gene GPT and peripheral arterial disease.