We have previously shown that high PTH in adenine-induced CKD is associated with high osteocyte RANKL expression in cortical bone and cortical porosity,9,12 indicating osteocyte RANKL plays a role in the development of cortical porosity in CKD; however, the direct role of bone cell RANKL in CKD has not been assessed. The gene discussed is PTH; the disease is chronic kidney disease.