Importantly, mice lacking osteocyte/osteoblast lineage RANKL (Dmp1-Cre/RANKLfl/fl mice) did not have adenine-induced CKD alterations to cortical bone; therefore, the lack of bone-derived RANKL via the Dmp1-Cre system prevented the declines in cortical thickness and progression of cortical porosity in CKD. The gene discussed is TNFSF11; the disease is chronic kidney disease.