IL-10, IL-6 (which is associated with duration of symptoms and recovery), and c-reactive protein (CRP) have been demonstrated to be elevated six hours after a mTBI (when inflammatory markers and symptom severity are at their peak), while downregulation in mRNA genes that respond to peripheral blood mononuclear cells (PBMCs) has been shown in sports-related concussions [11]. The gene discussed is IL6; the disease is concussion.