FOXO3 and breast carcinoma: The study conducted by Stan et al. found that FOXO3a and Bim were responsible for the induction of Withaferin A (WA) in MCF-7 and MDA-MB-231 cells, and WA’s pro-apoptotic effects through triggering breast cancer cells’ intrinsic apoptosis was attributed to the involvement of FOXO3a and Bim (Stan et al., 2008).