TRAIL-inducing compound 10 (Tic 10) can reduce the expression of cell division protein kinase 4 (CDK4) by activating FOXO3a, thereby reversing the resistance of the breast cancer T47D/5-Fu cells to 5-fluorouracil in vitro and in vivo (Song et al., 2018). Here, FOXO3 is linked to breast carcinoma.