FOXO3 and breast cancer: Fulvia Farabegoli et al. also demonstrated that co-administration of EGCG and 6-OH-11-O-hydroxyphenanthrene (IIF) could promote FOXO3a and its nuclear import from the cytoplasm of MCF-7, MCF-7TAM and MDA-MB-231 cells to inhibit the growth of breast cancer (Farabegoli et al., 2014).