FOXO3 and gastric cancer: Additionally, CircMRPS35 increases the acetylation of H4K5 in the promoter region of FOXO1 and FOXO3a by recruiting KAT7, thereby upregulating the upregulation of FOXO1 and FOXO3a, and finally inhibiting the proliferation and invasion of gastric cancer cells (Jie et al., 2020).